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Collectively, these functional alterations shift the gut toward a pro-inflammatory and neuroactive state, linking peripheral immune dysregulation to central dopaminergic neurodegeneration [50]

Clinical studies have shown that endothelial dysfunction, hyperlipidemia, oxidative stress, and platelet hyperactivity are important factors in the development of atherosclerotic vascular problems (2)

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Recent developments have begun to shed light on combination treatments with other therapies, such as chemotherapy, radiation therapy, immunotherapy, or targeted therapy (Secondini et al., 2017

Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents