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Stones can migrate from the gallbladder into the bile ducts (choledocholithiasis), potentially causing obstruction, jaundice, or acute pancreatitis

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For orforglipron, participants initiated on higher doses and those on rapid titration schemes appeared to have higher discontinuation rates, providing insights into the optimisation process for the phase 3 trials

Recent data suggest potential benefits in heart failure with preserved ejection fraction (HFpEF) with obesity, but monitoring is important, particularly during initiation