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Regulatory and Ethical Context The FDA has approved recombinant human IGF-1 only as mecasermin (Increlex) for the narrow indication of severe primary IGF-1 deficiency or GH-gene deletion with neutralising antibodies to GH, in children [15]

Clinical trials show participants lose an average of 15-22% of body weight over 68 weeks, yet individual timelines vary significantly based on genetics, lifestyle, and baseline health status

Addressing biological factors such as hormones, metabolism, and appetite regulation gives patients a real chance at lasting results

The gut microbiotas influence extends to the modulation of autoimmune responses through molecular mimicry

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