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Melatonin can reduce the action of PGE-2, allowing the secretion of IL-2, stimulating at the same time Th1 lymphocytes and monocytes to increase the release of other cytokines, such as IL-6, IL-12, IL-27, and TNF-, also regulators of NK cell proliferation [33,48]

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270 In an inflammatory response, activation of epithelial and immune cells triggers NOXs to generate ROS, which can directly kill microorganisms