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It is classified as a Category 2 bulk drug substance by the FDA, which restricts its availability through compounding pharmacies

It modulates GABA and serotonin activity in the brain, producing a calm, anxiolytic effect that quiets the racing thoughts and evening anxiety that prevent millions of people from falling asleep

This is probably where the idea that taking more vitamin B12 than you need will give you extra energy originally came from

When NNMT activity is high, the body may become less efficient at using stored fat for energy, which can contribute to stubborn weight, low energy, and frustrating plateaus