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Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

This is a cash-pay model, which means the full cost comes out of pocket every month

Author contributions ZX: Conceptualization, Data curation, Formal Analysis, Writing original draft, Writing review and editing

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Accordingly, an allele carrying a mutation that is beneficial would be selected for amplification, and/or the corresponding WT allele might be reduced or lost (e.g