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This localized depletion of the brain's master antioxidant is accompanied by abnormally high levels of ventricular lactate and free radicals, indicating that the brain is suffering from severe oxidative stress and impaired cellular energy metabolism

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Hence, inhibiting NADPH production in cancer cells would tentatively decelerate macromolecular biosynthesis and render the transformed cells to free radical-mediated damage [232]

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Glutathione and ROS scavenging Glutathione defends against reactive oxygen species that come from the respiratory chain