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Department of Medicine, University Medical Centre Mainz, Johannes Gutenberg University, Mainz, Germany, Mainz, Germany, (2)University Medical Center Mainz, (3)University of Mainz, Mainz, Germany, (4)Nordic Bioscience a/S, Denmark, (5)Nordic Bioscience a/S, (6)Histoindex Pte Ltd, Singapore, (7)Histoindex Pte Ltd, (8)Nordic Bioscience A/S, (9)Metabolic Liver Research Program, Department of Medicine, University Hospital Mainz, Mainz, Germany Background: In NAFLD hepatic fibrosis develops slowly over time

Furthermore, these haplotype associations require further analysis to exclude nearby HLA gene variantswhich may influence the observed immune phenotype due to linkage disequilibrium with specific C4 alleles (123)

2014;75 Suppl 1:S41

We observed perturbation of the T-lymphocyte compartment in fibrosis with underrepresentation of the NK populations and expansion of CD4/CD8 cells