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seen on the lip, the tongue, inside the mouth Based on the variants, they may be classified as: Volar Melanotic Macule, which is seen in the palms and soles Ungual Melanotic Macule, involving the nail apparatus Reticulated Melanotic Macule, developing on the skin due to sun-exposure PUVA-Lentigines, which occurs as a side effect of PUVA therapy given for various skin conditions The presence of numerous Melanotic Macules on the body may be associated with a variety of syndromes including Carney complex, Peutz-Jeghers syndrome, and LEOPARD syndrome

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What proximal pharmacodynamic biomarkers should we measure