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People with a personal or family history of medullary cell carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2) should avoid semaglutide

This mechanism is especially evident and accelerated in stressed out women experiencing weight loss resistance

Additionally, metabolism adjusts during weight loss

In the FLOW trial, participants with DKD and T2D treated with semaglutide experienced clinically meaningful weight loss (mean difference -3.5 kg compared to placebo), supporting its value in managing obesity-related metabolic stress in the context of CKD[10]

A Randomized Controlled Trial of The GLP-1 Receptor Agonist Dulaglutide in Primary Polydipsia