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On the cardiovascular side, the SUSTAIN-6 trial in 2016 was one of the first to report a significant reduction in major adverse cardiovascular events with semaglutide in adults with type 2 diabetes and high cardiovascular risk (Marso et al., NEJM, 2016)

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Given that people may need to take medications long term, this raises not only financial and coverage determination questions, but it can affect physical health

Beyond 12 months: Every 3-6 months for stable patients

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