surmount 1 tirzepatide SURMOUNT-1 (NEJM 2022) tested — a dual GIP/GLP-1 receptor agonist — in 2,539 adults with obesity and achieved up to 20.9% mean weight loss at the highest dose. 57% of participants SURMOUNT-1: Tirzepatide results in 22.5%

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Method performance testing demonstrated acceptable method precision, accuracy, and linearity, and the standard addition experiment showed that BSA is a suitable surrogate matrix

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The 1.7-fold accumulation means your trough at steady state is meaningfully higher than your trough after the first injection