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these enzymes use endogenous adenosine triphosphate (ATP) to generate biotinyl-5-adenosine monophosphate, a mixed anhydride that reacts with lysine side chains

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mansoni TGR inactivation by OPZ ranged from 16.3 10 3 min 1 to 355.5 10 3 min 1 for GR activity and from 11.0 10 3 min 1 to 58.9 10 3 min 1 for TrxR activity, within the log-linear range of the inhibition curve