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Leenen et al., 1993) on the functioning and synthesis of CTS in the brain (hypothalamus) have been substantiated (Kawamura et al., 1999

The purpose of the IOMC is to promote coordination of the policies and activities pursued by the Participating Organizations, jointly or separately, to achieve the sound management of chemicals in relation to human health and the environment

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Permeation enhancers Achieving sufficient intranasal bioavailability is critical for medications intended for CNS delivery

These include the expression of key antioxidant enzymes such as superoxide dismutases (SOD1, SOD2), catalase (CAT), and glutathione peroxidase (GPx) (Figure 1) (Valle-Prieto and Conget, 2010)