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Similarly, women approaching perimenopause may find that weight loss and metabolic changes exacerbate existing hormonal fluctuations

However, further trials with larger and various population and longer follow-up are needed

Although the benefits of GLP-1 RAs in HF (particularly HFrEF) and CAD remain less definitive, emerging data suggest potential roles in improving PAD and blood pressures, reducing symptoms in HF, and possibly lowering the risk of AF

Initiation of GLP-1 therapy follows a gradual dose-escalation protocol designed to minimize gastrointestinal adverse effects while achieving therapeutic benefit

Unlike GHRP-2 or GHRP-6, ipamorelin doesn't meaningfully raise cortisol or prolactin, making it a cleaner option for women who are sensitive to hormonal fluctuations