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Melanogenically active melanocytes/nevomelanocytes in the lamina propria also have the capacity to cause oral mucosal melanin hyperpigmentation [34]

B Vitamins Support energy metabolism and may reduce fatigue during the weight loss process

10.1124/dmd.30.3.331 Drug Metab

Importantly, initiation of GLP-1RA may decrease levothyroxine dose requirements in patients with hypothyroidism through weight loss, enhance levothyroxine absorption due to delayed gastrointestinal (GI) transit, and have direct effects on the hypothalamic-pituitary-thyroid axis [23,24,25,26,27,28,29], potentially increasing the risk of thyroid hormone over-replacement (i.e., iatrogenic hyperthyroidism)

References 1 SYMLIN (pramlintide acetate) FDA Prescribing InformationOfficial U.S