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A subset of participants underwent body composition analysis, revealing that the majority of weight loss was from fat mass with relative preservation of lean mass, an important finding given concerns about muscle loss with rapid weight reduction

Through activation of these receptors, it enables investigation of integrated endocrine signaling pathways that regulate cellular energy sensing, metabolic enzyme activity, and nutrient responsive signaling in laboratory models[5]

Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling

Edwards K et al