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10.1016/j.jchromb.2017.07.001 40 TakiY.HashizumeH.SassaY.TakeuchiH.WuK.AsanoM.et al (2011)

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At neutral pH, peptides with hydrophobic sequences or isoelectric points near or above physiological pH tend to self-associate through hydrophobic interactions and hydrogen bonding forming insoluble aggregates or gels that resist dissolution

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