TXNIP, in particular, achieves bidirectional autophagy regulation by engaging with distinct target proteins, such as the metabolic regulators mTOR and AMPK, the stress sensor REDD1, the master transcription factor TFEB, and by influencing the PI3K/Akt/mTOR signaling pathway
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and (3) whether CAF and PXN influence the same mechanistic targets known to enhance cognition: neurotransmitter levels, -amyloid production, BDNF, and antioxidant capacity
[11] Tirzepatide is a prescription medication approved by the FDA for the treatment of type 2 diabetes (under the brand name Mounjaro) and chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity (under the brand name Zepbound)
The set of features that contributed most significantly to the definition of each component was incorporated into the training multilayer dataset (Supplemental Figure S2)