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Most commonly, underlying chronic venous insufficiency is the culprit, but they can also be the result of trauma, chemotherapy, autoimmune disorders, and corticosteroid administration

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Protein binders were preincubated with approximately one 80% inhibitory concentration (IC 80 ) of -cobratoxin or ScNtx at various toxin-to-binder molar ratios (1:1, 1:3, 1:9 and 1:27) and then added to the cells