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Our differentiation protocol positions these four timepoints as critical for liver organoid development and maturation: Day 7 represents the hepatoblast differentiation stage, Day 15 marks the early hepatocyte stage, and Day 30 and Day 45 indicate distinct stages of liver organoid maturation towards achieving appropriate liver functions with an increasing population of liver cells

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10.1016/j.phymed.2018.09.212 63 KhanM

Phase I study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors