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This enhancement in gut health is associated with improved cognitive performance and reduced systemic inflammation, suggesting that the neuroprotective effects of semaglutide are partially mediated by this complex axis ( Despite substantial mechanistic and preclinical evidence indicating neuroprotective effects, translating these findings into clinical benefits has proven challenging

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1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: Implication for behavioral influences of vitamin D