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For example, patients with lupus often have glutathione deficiency, and studies have shown that replenishing it significantly reduces their symptoms

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Peer review Peer review information Nature Communications thanks Karl Hoffmann, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

PARP1 KO HeLa cells were transfected with PARP2 or control siRNA with or without 10 M olaparib treatment

Thus, roGFP2 oxidation by PfGrx occurs preferentially via a glutathione-dependent monothiol and not a glutathione-independent dithiol mechanism (Fig