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Furthermore, as dysregulated glucagon secretion is a key pathogenic mediator of T1DM and T2DM (98) and mouse models of beta-cell destruction (99) report that insulin deficiency is accompanied by an increase in alpha-cell mass, which has served as rationale for the notion that a loss of beta-cell paracrine signaling drives alpha-cell proliferation

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Scientists still arent sure what causes ASD, but evidence suggests its probably the result of complex interactions between genetic and environmental factors that affect brain development

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