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PMC.ncbi.nlm.nih.gov

Many supplements, especially herbal products, have the potential to interact with commonly prescribed medications and may lead to dangerous side effects

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at high doses, it overwhelms and glucuronidation/CYP2E1 take over) Bile acids Catecholamines (dopamine, norepinephrine, epinephrine) Cholesterol DHEA and steroid hormones Estrogens Minoxidil (requires sulfation for activation) Thyroid hormones Sulfation is not always detoxifying