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NMDA receptors are an exemplar of this dynamic at work, where the balance between primarily inhibitory effects of NO-mediated NMDA receptor nitration and the bimodal and highly concentration-dependent effects of extracellular polyamines at NMDA receptors put interactive guardrails around the range of permitted NMDA calcium flux (Figure 2

Timelines matching mechanisms: Gene expression changes happen rapidly (hours to days) but take weeks to months producing measurable effects as new proteins accumulate

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BPC-157 shows remarkable stability and can be administered orally with some retained activity, unlike most peptides which degrade in the digestive system

Zhao L, Wu Q, Wang X, Wang S, Shi X, Shan Z