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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Wilding J.P.H., Batterham R.L., Calanna S., Davies M., Van Gaal L.F., Lingvay I., McGowan B.M., Rosenstock J., Tran M.T.D., Wadden T.A., Wharton S., Yokote K., Zeuthen N., Kushner R.F., STEP 1 Study Group Once-weekly semaglutide in adults with overweight or obesity

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In preclinical characterization studies (Coskun et al., 2022, Molecular Metabolism), retatrutide demonstrated potent agonist activity at all three target receptors: GIP receptor : High-potency agonism derived from the GIP backbone scaffold

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