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In SURMOUNT-1, the most common treatment-emergent adverse events were gastrointestinal: nausea (24.6-33.3% across doses vs 9.5% placebo), diarrhea (18.7-21.2%), vomiting (5.7-12.2%), and constipation (5.8-11.5%)

Shaking creates those destructive shearing forces we talked about

Severe or worsening reactions across multiple sites may signal need for formulation adjustment or technique review

[4] The work observed that models exposed to MT-1 exhibited a reported 75% increase in pigmentation and roughly 47% less burn