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50 Annular stabbing with needles in animal model consistently triggers disc degeneration, characterized by loss of disc height, hydration and proteoglycans and by the expression of inflammatory, catabolic and fibrotic proteins
In consultation with the clinical experts, no major concern with the generalizability of results due to this difference was identified
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Patients should remain upright for at least 2-3 hours after meals, particularly dinner, to facilitate digestion and reduce discomfort
The starter dose allows careful monitoring for side effects while supporting gradual adjustment to the treatment plan
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