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System Xc transports cystine (an alternative precursor of GSH) into cells and exports an equivalent number of glutamate out of the cells through solute carrier family 3 member 2 and solute carrier family 7 member 11 (SLC7A11) transporters (Lu et al., 2024

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[2] Kraus D, et al

Notably, over the subsequent 6 days, we observed a sustained body-weight-lowering effect after infusion of GLP-1MK-801, but not semaglutide, suggesting that the targeted inhibition of NMDA receptors in GLP-1 receptor-positive neurons might promote sustained changes to the defended level of adiposity

Prevalence of obesity and severe obesity among adults: united states, 20172018 (2020)