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Note that these mutants are based on the KOS strain, so we compared them to the corresponding wild-type parental strain

Clinical trials of anti-inflammatory treatments (TNF- antagonist infliximab, minocycline) have shown preferential benefit in patients with elevated inflammation biomarkers prior to treatment [271, 272]

Li H, Klett DE, Littleton R, Elder JS, Sammon JD

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By heavily promoting GDNF expression, it reduces brain inflammation, clears out metabolic waste (like the amyloid plaques associated with aging), and revitalizes the dopamine system heavily taxed by modern life, stress, and previous stimulant use