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A network meta-analysis published recently confirmed this pattern, finding that retatrutide demonstrated greater absolute weight reduction compared to tirzepatide (retatrutide: MD -16.34 kg vs tirzepatide: MD -11.82 kg)

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Marsicano and Lutz, 1999)

Reimbursement data shows a marked increase in spending in Q3 and Q4 , likely due to more aggressive prescribing for weight loss: Q1 2024: ~$65M Q2 2024: ~$70M Q3 2024: ~$170M Q4 2024: ~$190M Unlike Ozempic, Wegovy reimbursements were more evenly distributed across dosage levels , from 0.25mg up to the full 2.4mg dose

Dose flexibility favors compounded tirzepatide