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Intranasal administration of the optimized formulation exhibited 5.5 times greater relative bioavailability than oral administration of the drug solution, which was attributed to the avoidance of the first-pass effect and enhanced drug permeation across the nasal mucosa

Key Takeaways Fluoxetine is a daily medication for ongoing anxiety, while trazodone is fast-acting for situational stress

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Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ER