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This measure aims to promote the appropriate use of beta-blocker therapy in select patients with heart failure with reduced ejection fraction (HFrEF)

Effects of (poly)phenols on cardiometabolic health: epidemiological evidence Currently, a significant number of meta-analyses focusing on observational studies investigating associations between (poly)phenols and health outcomes have been published

For example, participants with chronic kidney disease reported changes in IL-1, IL-6, and MMPs-9 and -12 (106), while we observed changes in IL-6, TARC/CCL17, IL-17A, I-TAC/CXCL11, Eotaxin-2/CCL24, Eotaxin/CCL11, and MIP-1a in our AD study participants (99)

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Thus, NACs neuroprotective effects may involve its ability to reduce cortical spermidine levels and thereby limit local excitotoxic effects in the PFC during THC exposure, further indicated by our electrophysiological findings demonstrating a hyperactive neuronal mPFC phenotype