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Endotoxin testing helps identify the presence of bacterial byproducts that could introduce unwanted variables into laboratory investigations

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Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema

When symptoms do occur, they usually reflect underlying conditionssuch as liver disease, haematological disorders, or renal impairmentrather than the elevated vitamin itself

Brookes TS, Barlow R, Mohandas P, Bewley A