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Interestingly, among the proteins that showed increased phosphorylation, most of them were synaptic proteins associated with pre-synaptic short-term plasticity (e.g., Syn1, Rims1), post-synaptic density structure (e.g., scaffolding proteins, actin remodeling), glutamate receptors (e.g., Grin2b/5), or inhibition of translation (e.g., AMPK) (Wang et al., 2018)

But it can also prevent the loss of neurons that are important for brain function

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Bottom line on safety: If someone considers peptide therapy, it should be under medical supervision with pre-treatment screening (baseline GH/IGF-I, metabolic panel, glucose), ongoing monitoring, and sourcing from reputable, traceable suppliers under a lawful framework