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The majority of hepatotoxins damage centrilobular hepatocytes, most probably as a result of oxidative activation to electrophilic intermediates by the CYP isoforms located in the centrilobular region (Lindros 1997)
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Given the small sample size of this Study, it was not sufficiently powered for statistical significance analysis, which will be a key part of any expanded studies with DehydraTECH GLP-1 undertaken in the future
Gradual titration helps reduce the likelihood and intensity of these reactions
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