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Current Diabetes Reviews, 19(9)

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

Key target genes include those encoding components of the electron transport chain (ATP synthase subunits, cytochrome c), fatty acid oxidation enzymes (medium-chain acyl-CoA dehydrogenase, carnitine palmitoyltransferase 1), and transcription factors that amplify the metabolic signal (PGC-1 itself, NRF-1)

MCOLN1/ cells show obvious Fe 2+ deposition in lysosomes and cause cellular iron metabolism disorder and neuronal degeneration (Figure 3)

However, many questions remain about their control and modulation of repair, and it appears that their effects depend on many determinants, including timing, levels, specific binding to receptors, and interaction with other factors