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Loke MF, Chua EG, Gan HM, Thulasi K, Wanyiri JW, Thevambiga I, Goh KL, Wong WF, Vadivelu J

5 , 3 , and 4 subtypes similarly play negative regulatory roles in nicotine uptake and aversive effects (Sheffield et al., 2000)

Lower respiratory tract barriers and low-biomass microbiota The lower respiratory tract (LRT), comprising the trachea, bronchi, and alveoli, harbors bacterial communities with significantly lower abundance and diversity compared to the URT 95,109

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Alveolar hypoxia increases gene expression of extracellular matrix proteins and platelet-derived growth factor-B in lung parenchyma