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Longer-acting weekly formulations like semaglutide and dulaglutide reach steady-state concentrations more slowly than daily preparations but may offer more consistent effects

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If using a metered-dose spray pump for the first time, actuate the pump 3-5 times pointed away from the face until a fine mist appears

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Risk factors that increase this concern include: History of peptic ulcer disease or gastrointestinal bleeding Concurrent use of anticoagulants (warfarin, apixaban) or antiplatelet agents (aspirin, clopidogrel) Use of corticosteroids or selective serotonin reuptake inhibitors (SSRIs) Chronic alcohol consumption Presence of Helicobacter pylori infection For patients taking low-dose aspirin for cardiovascular protection, ibuprofen can interfere with aspirin's antiplatelet effect