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Hakaru Hashimoto The first indication of an immunologic abnormality in this disease was an elevation of the plasma gamma globulin fraction detected by Fromm et al.(3) This finding, together with abnormalities in serum flocculation test results(4) indicated that the disease might be related to a long-continued autoimmune reaction

Menopause is a turning point for the development of metabolic dysfunction-associated steatotic liver disease (MASLD) (previously termed nonalcoholic fatty liver disease)

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation