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Assumption: Endosomal GLP-1R signaling amplifies therapeutic output

In particular, liraglutide and taspoglutide stand out for their cholesterol-lowering effects, notably impacting total cholesterol and triglycerides, showcasing a broader therapeutic impact beyond glucose modulation [50]

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A 2012 study published in Journal of Pharmacology and Experimental Therapeutics demonstrated that a seven-day dihexa dosing protocol produced cognitive improvements in rodent models that persisted for at least 30 days post-treatment, despite the compound being undetectable in plasma within 12 hours of the final dose

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