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It is important to be clear that these findings come largely from preclinical (animal and cell) models, and that a described mechanism is not the same as a proven result in people

Mitochondria serve as the energy factories of cells, and the development of eggs necessitates a substantial amount of ATP (Richani et al., 2021)

In another study, mental health diagnoses were prevalent among cirrhosis patients and significantly increased the risk of all-cause mortality: 54% for any mental health diagnosis, 11% for non-alcohol-use disorder (AUD)/substance-use disorder (SUD), and 44% for AUD/SUD

Thus we have targeted the dimerization process by developing molecules that mimic the dimerization domain, the hinge region, with idea that they can act as dominant negative replacements