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Whereas the role of des-acyl (des-octanoyl) ghrelin in activating GHS-R1a is still debated, it has been suggested that des-acyl ghrelin can influence food intake by mechanisms independent of GHS-R1a (Toshinai et al., 2006) and by modulation of insulin sensitivity (Heppner et al., 2013)

Final approval follows a full medical evaluation

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TRIUMPH-1's prespecified 104-week extension (BMI 35 subgroup) showed average weight loss reaching 30.3% higher than the 28.3% at week 80

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