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Practical Tips for Managing CIPN at Home In addition to medical treatments, there are steps you can take at home to manage symptoms: Protect Your Feet and Hands: Wear padded gloves and comfortable, supportive shoes to avoid injury

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135 Further, PRAS40 and mTOR also exerts negative feedbacks on proximal insulin signaling, PRAS40 knockdown significantly decreases Akt phosphorylation, mTORC1 binds and inhibits INSR by inducing destabilization of IRS1