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The second mechanism by which glutathione causes lightening of skin is inhibition of transfer of tyrosinase to premelanosomes for melanin synthesis.[] The third mechanism of tyrosinase inhibition is through its antioxidant effect as it scavenges the free radicals generated in the epidermis following UV light irradiation

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However, futile quinone redox cycling can lead to a cascade of ROS formation and as such, the link between toxicity and quinone redox cycling is widely acknowledged 5

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Approved for long-term use (more than 12 weeks)