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Most participants who complete titration find their symptoms manageable or resolved by the maintenance phase

13 , 14 , 15 This may well relate to participants who received semaglutide in STEP 1 having achieved greater weight loss prior to withdrawal than in other trials, and thus having greater potential for regain, driven by physiological and behavioural factors

Melena versus hematochezia [edit] Bleeds that originate from the lower gastrointestinal tract (such as the sigmoid colon and rectum) are generally associated with the passage of bright red blood, or hematochezia, particularly when brisk

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