Basel: Karger (2012)
Gastrointestinal adverse effects are the most frequently reported and include: Nausea (very common, affecting more than 1 in 10 people according to the SmPC) Vomiting Diarrhoea Constipation Abdominal pain or discomfort These symptoms are usually mild to moderate, transient, and tend to improve over time as the body adjusts to the medication
They: Slow gastric emptying Reduce appetite Reduce overall intake But downstream, that means: Less food less stool Less fluid drier stool Slower motility slower transit And then patients unintentionally make it worse: Eating mostly protein Skipping vegetables Drinking less (because theyre not thirsty) So the colon ends up with less volume, less water, and slower movement
Asnis, MD, FACE, DABOM, director of The Center for Weight Management at Stamford Health and assistant clinical professor of medicine at Columbia University Vagelos College of Physicians and Surgeons, GLP-1 microdosing is the new buzzy term circulating in the conversation regarding these tools for weight management
doi: 10.1201/b16472 [DOI] [Google Scholar] 113.Baumann MH, Ayestas MA, Dersch CM, Brockington A, Rice KC, Rothman RB
