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Patients with euDKA had a median increase in ICU length of stay of 3 days compared to controls ( The Black Swan Argument: Anesthesiologists argue that while the incidence might be statistically low (supporting the JAMA data), the consequence is catastrophic
Patients with genetic markers indicating higher GLP-1 receptor sensitivity may require lower tirzepatide starting doses or wider injection spacing, whereas those with reduced receptor activity may benefit from faster dose escalation schedules
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