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In high-altitude cerebral edema (HACE) which is characterized by inflammation and hypoxia, proteins in the nucleosome remodeling and histone deacetylase (NuRD) complex of microglial is lactylated, which upregulates the expression of various pro-inflammatory factors in M1-type microglia and enhances NF-B pathway activity, thereby exacerbating LPS-induced neuroinflammatory conditions [133]

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c.4254_4257del (tgag), p.E1419Wfs*12) spanned the length of the KAT6A-coding region (Fig 1A)

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Its important to note that if your B12 levels are already normal, additional injections are unlikely to boost your energy